Two functionally distinct pools of Src kinases for PDGF receptor signalling.
نویسندگان
چکیده
The cytoplasmic tyrosine kinases of the Src family (SFK) play important roles in cell responses induced by growth factors, including cell growth, survival and migration. Here, we review how SFK participate in PDGF (platelet-derived growth factor) receptor signalling leading to DNA synthesis and actin assembly. Furthermore, evidence for a spatial compartmentalization of SFK signalling is also discussed.
منابع مشابه
Two distinct pools of Src family tyrosine kinases regulate PDGF-induced DNA synthesis and actin dorsal ruffles.
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 33 Pt 6 شماره
صفحات -
تاریخ انتشار 2005